Pulse oximetry beyond oxygen saturation: Early waveform characteristics in sepsis patients with adverse outcomes - A proof-of-concept study
Authors' conclusion
This study highlights the potential use of PPG as a valuable tool for detecting early cardiovascular changes in sepsis.
Study context
- Population
- Patients with early sepsis at the emergency department (ED)
- Participants
- 576 patients
- Comparison
- PPG features in patients who deteriorated vs those who did not
- Primary endpoint
- Composite of:
- ICU admission
- In-hospital mortality
- Follow-up
- 48 h
Methodological detailsproof-of-concept
- Proof-of-concept
Primary result
As reported in the abstract
PPG features, first 20 min after ED arrival · first 20 min after ED arrival
| Group | Value | SPA | DPA | PI |
|---|---|---|---|---|
| Deteriorated | 1218 AU | 1218 | 462 | 0.540 s |
| Not deteriorated | 1490 AU | 1490 | 621 | 0.609 s |
Value
Deteriorated1218 AU
Not deteriorated1490 AU
SPA
Deteriorated1218
Not deteriorated1490
DPA
Deteriorated462
Not deteriorated621
PI
Deteriorated0.540 s
Not deteriorated0.609 s
- Deteriorated vs Not deteriorated: P < 0.001 — lower in Deteriorated
- Deteriorated vs Not deteriorated: P < 0.001 — lower in Deteriorated
- Deteriorated vs Not deteriorated: P < 0.001 — shorter in Deteriorated
- APG b/a ratio lower (−0.881 vs. −0.802)
- P < 0.001
Further findings
SBP, DBP, MAP
- SBP did not differ between groups (123 vs. 129 mmHg)
- P = 0.186
- DBP did not differ between groups (78 vs. 76 mmHg)
- P = 0.400
- MAP did not differ between groups (88 vs. 95 mmHg)
- P = 0.111
HR and correlation with PPG-derived PI
- HR significantly different (111 vs. 99 bpm)
- P = 0.001
- HR and PPG-derived PI strongly correlated
- ρ = −0.921
Original publication
Pulse oximetry beyond oxygen saturation: Early waveform characteristics in sepsis patients with adverse outcomes - A proof-of-concept study. J Crit Care. Published 16 May 2025. doi:10.
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