Quantified Ataxic Breathing Can Detect Opioid-Induced Respiratory Depression Earlier in Normal Volunteers Infused with Remifentanil
Authors' conclusion
AB was frequently present in the absence of traditionally detected OIRD as defined by reduced mental alertness (MOAA/S score of <4) and bradypnea (RR <8 breaths/min).
Study context
- Population
- Healthy volunteers receiving escalating remifentanil with low baseline dose of propofol121 assessments
- Participants
- 26 volunteers
- Comparison
- Quantified ataxic breathing vs conventional opioid-induced respiratory depression (OIRD) detection
- Outcome
- Sensitivity and specificity for AB to detect OIRD
Methodological detailshealthy volunteers, escalating remifentanil target effect-site concentrations, support vector machine learning
- Healthy volunteers
- Escalating remifentanil target effect-site concentrations
- Support vector machine learning
Performance
As reported in the abstract
Detection of OIRD by the conventional method
| Test or model | Sensitivity | Specificity |
|---|---|---|
| Ataxic breathing (AB) | 92% | 28% |
Ataxic breathing (AB)
Sensitivity92%
Specificity28%
Further findings
| Outcome | Values |
|---|---|
| At least moderate AB in instances not diagnosed as OIRD by conventional measures | AB 72% |
Original publication
Quantified Ataxic Breathing Can Detect Opioid-Induced Respiratory Depression Earlier in Normal Volunteers Infused with Remifentanil. Anesth Analg. Published 23 August 2024. doi:10.
Composed by AI from the published abstract and checked against it. How Briefs are made →