A randomised controlled trial of intravenous dexmedetomidine added to dexamethasone for arthroscopic rotator cuff repair and duration of interscalene block
Primary result · Time to first oral morphine intakeResult — go to the resultHazard ratio 1.68 95% CI 1.00–2.82Authors' conclusion
In conclusion, dexmedetomidine shortened the time to oral morphine consumption after interscalene block combined with dexamethasone and caused intra-operative hypotension.
Study context
- Population
- Day-case arthroscopic rotator cuff repair with interscalene brachial plexus block after IV dexamethasone 0.15 mg.kg-1
- Participants
- 122 participants
- Comparison
- Dexmedetomidine vs Placebo
- Dexmedetomidinen = 60
- Placebon = 62reference
- Primary endpoint
- Time from block to first oral morphine intake
- Follow-up
- First 48 postoperative hours
Primary result
Time to first oral morphine intake
Hazard ratio
1.68
95% CI 1.00–2.82
P = 0.049
Dexmedetomidine vs Placebo
HR 1.68 (95% CI 1.00–2.82); P = 0.049
As reported in the abstract
Further findings
Median, mg
| Outcome | Dexmedetomidine | Placebo | Difference (mg) (95% CI) | P value | |
|---|---|---|---|---|---|
| Morphine dose | 10 (IQR [range] 0-30 [0-50]) | 0 (IQR [range] 0-12.5 [0-50]) | 7 (0–10) | P = 0.056 | |
| −5051015Difference, mg (linear scale) |
Events
| Outcome | Dexmedetomidine | Placebo | P value |
|---|---|---|---|
| Participants taking oral morphine | 34 | 25 | P = 0.10 |
- Participants taking oral morphine: 25/62 vs 34/60
Pain at rest or on movement
- No effect of dexmedetomidine
Other outcomes, incl. durations of sensory and motor block
- Similar
Safety
Events
| Outcome | Dexmedetomidine | Placebo | P value |
|---|---|---|---|
| Intra-operative hypotension | 50 | 27 | P < 0.001 |
- Intra-operative hypotension: 27/62 vs 50/60
Original publication
A randomised controlled trial of intravenous dexmedetomidine added to dexamethasone for arthroscopic rotator cuff repair and duration of interscalene block. Anaesthesia. Published 14 December 2022. doi:10.
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