Hemodynamics, fluids & transfusion
Red Cell Transfusion in Critically Ill and Noncritically Ill Patients With Acute Myocardial Infarction and Anemia—A Subanalysis of the Myocardial Ischemia and Transfusion (MINT) Trial
Authors' conclusion
There is no evidence that the overall MINT trial results, which generally favor a liberal transfusion strategy in AMI patients, apply differently to noncritically ill and critically ill patients.
Study context
- Population
- Adults with acute myocardial infarction (AMI) and anemia in the MINT trial; critically ill = treated in an ICU at randomization; 144 sites in US, Canada, France, Brazil, New Zealand, Australia1,679 (47.9%) critically ill
- Participants
- 3,504 adults
- Comparison
- Restrictive vs Liberal
- Primary endpoint
- Death and composite of death/MI
- Follow-up
- 30 days
Methodological detailssubgroup analysis, parallel, two-arm, multicentre
- Subgroup analysis
- Parallel, two-arm
- Multicentre
Primary result
As reported in the abstract
Death and death/MI by subgroup
Restrictive vs LiberalRelative risk (95% CI)
Death, noncritically ill
1.09(0.77–1.54)
death/MI, noncritically ill
1.09(0.85–1.38)
Death, critically ill; interaction p = 0.55
1.24(0.95–1.61)
death/MI, critically ill; interaction p = 0.52
1.21(0.99–1.47)
Further findings
Death and death/MI, critically ill vs noncritically ill patients · 30 days
- Death, critically ill vs noncritically ill
- 11.9% vs. 6.5%
- Death/MI, critically ill vs noncritically ill
- 18.9% vs. 12.7%
Original publication
Red Cell Transfusion in Critically Ill and Noncritically Ill Patients With Acute Myocardial Infarction and Anemia—A Subanalysis of the Myocardial Ischemia and Transfusion (MINT) Trial. Crit Care Med. Published 27 May 2026. doi:10.
Composed by AI from the published abstract and checked against it. How Briefs are made →