Reduced Lymphatic Activity During Positive Pressure Ventilation and General Anesthesia—A Cause of Postoperative Edema?
Authors' conclusion
Peripheral lymphatic activity is reduced during PPV with general anesthesia compared to awake, spontaneously breathing individuals. The effect was present even at standard ventilatory settings
Study context
- Population
- Individuals undergoing corrective jaw surgery
- Participants
- 21 individuals
- Exposure
- Spontaneous respiration vs mechanical ventilation (standard and elevated PEEP, ventilation pause) under GA vs post-operative
- Outcome
- Peripheral lymphatic contraction frequency (near-infrared fluorescence imaging, left lower limb)
Main finding
As reported in the abstract
Peripheral lymphatic contraction frequency
95% CI 0.49–1.08; P < 0.001
Observational data: associations, not effects.
Further findings
Peripheral lymphatic propulsion velocity
- No significant change between any of the investigations
Completely inactive vessels
- More vessels completely inactive during PPV vs spontaneous breathing
Parts of this Brief are withheld: the automatic checks could not confirm them against the abstract.
Original publication
Reduced Lymphatic Activity During Positive Pressure Ventilation and General Anesthesia—A Cause of Postoperative Edema? Acta Anaesthesiol Scand. Published 5 June 2025. doi:10.
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