Respiratory failure & ventilation
Relationship between D-dimers and dead-space on disease severity and mortality in COVID-19 acute respiratory distress syndrome: A retrospective observational cohort study
Authors' conclusion
We report no association between dead space and inflammatory markers in mechanically ventilated patients with C-ARDS.
Study context
- Population
- Mechanically ventilated patients with COVID-19 ARDS (C-ARDS), first 24 h of invasive ventilation
- Outcome
- Relationship between dead space indices, markers of inflammation, immunothrombosis, severity and ICU mortality
Main finding
As reported in the abstract
Correlation of D-dimers with dead space indices
D-dimers vs VR, weak relationship
r = 0.07
p = 0.13
D-dimers vs PETCO2/PaCO2, weak relationship
r = −0.1
p = 0.02
D-dimers vs estimated dead space fraction, weak relationship
r = 0.019
p = 0.68
Observational data: associations, not effects.
Further findings
D-dimers and ferritin across C-ARDS severity categories
- Not significantly different across severity categories
Intensive care unit (ICU) mortality
- Age, PaO2/FiO2, pH, PETCO2/PaCO2 and ferritin independently associated with ICU mortality
Original publication
Relationship between D-dimers and dead-space on disease severity and mortality in COVID-19 acute respiratory distress syndrome: A retrospective observational cohort study. J Crit Care. Published 26 April 2023. doi:10.
Composed by AI from the published abstract and checked against it. How Briefs are made →