Relationship between residual gastric content and peri‐operative semaglutide use assessed by gastric ultrasound: a prospective observational study
Main finding · Increased residual gastric contentResult — go to the resultOdds ratio 36.97 95% CI 16.54–99.32Authors' conclusion
Pre-operative semaglutide use within 10 days of elective surgical procedures was independently associated with increased risk of residual gastric content on pre-operative gastric ultrasound assessment.
Study context
- Population
- Patients undergoing elective surgical procedures, assessed by pre-operative point-of-care gastric ultrasound
- Participants
- 220 patients
- Exposure
- Semaglutide vs Non-semaglutide
- Semaglutiden = 107
- Non-semaglutiden = 113reference
- Outcome
- Increased residual gastric content (any solid content or > 1.5 ml.kg-1 of clear fluids on gastric ultrasound)
- Follow-up
- Day of surgery, pre-operative
Methodological detailspropensity-weighted analysis
- Propensity-weighted analysis
Main finding
Increased residual gastric content
Odds ratio
36.97
95% CI 16.54–99.32
Events by group
Semaglutide vs Non-semaglutide
OR 36.97 (95% CI 16.54–99.32)
As reported in the abstract
Observational data: associations, not effects.
Further findings
Other factors associated with increased residual gastric content (propensity-weighted analysis)
- Age, OR
- 0.95 (95%CI 0.93-0.98)
- Male sex, OR
- 2.28 (95%CI 1.29-4.06)
Safety
Pulmonary aspiration of gastric contents
- No cases of pulmonary aspiration
Original publication
Relationship between residual gastric content and peri‐operative semaglutide use assessed by gastric ultrasound: a prospective observational study. Anaesthesia. Published 22 October 2024. doi:10.
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