Remimazolam for procedural sedation: A systematic review with meta-analyses and trial sequential analyses
Pooled result · Sedation success rateResult — go to the resultRR for sedation success 1.04 97.5% CI 0.96–1.14Authors' conclusion
Remimazolam seems to provide a similar sedation success rate as other active comparators (propofol, ciprofol, midazolam, dexmedetomidine, etomidate), although subgroup analyses indicated that remimazolam increased sedation success rate compared to midazolam.
Study context
- Population
- Adults undergoing procedural sedation
- Participants
- 13,953 adults · 63 trials
- Comparison
- Remimazolam vs placebo or active comparators
- Outcome
- Sedation success rate
Methodological detailstrial sequential analysis, GRADE
- Trial sequential analysis
- GRADE
Pooled result
As reported in the abstract
RR for sedation success
1.04
97.5% CI 0.96–1.14
P = 0.26
Remimazolam vs Active comparators
RR for sedation success 1.04 (97.5% CI 0.96–1.14); P = 0.26
Further pooled results
Sedation success rate by comparator (subgroup)
- Remimazolam vs midazolam increased sedation success rate; similar vs other comparators
Safety
| Outcome | RR (97.5% CI) | P value | |
|---|---|---|---|
| Respiratory complicationsTSA-adjusted CI 0.35 to 0.61 | 0.47 (0.36–0.61) | P < 0.01 | |
| Cardiovascular complicationsTSA-adjusted CI 0.38 to 0.57 | 0.46 (0.37–0.56) | P < 0.01 | |
| 0.20.5125Relative risk (log scale) |
Respiratory and cardiovascular complications by comparator (subgroup)
- Reduced vs propofol; similar vs midazolam
Original publication
Remimazolam for procedural sedation: A systematic review with meta-analyses and trial sequential analyses. Eur J Anaesthesiol. Published 4 February 2025. doi:10.
Composed by AI from the published abstract and checked against it. How Briefs are made →