Remimazolam vs. propofol for general anaesthesia in elderly patients: a meta-analysis with trial sequential analysis
Pooled result · Postinduction and intra-operative hypotensionResult — go to the resultRelative risk 0.41 95% CI 0.27–0.62Authors' conclusion
Remimazolam significantly reduced the risk of hypotension, bradycardia and injection pain, despite an increase in the time to loss of consciousness.
Study context
- Population
- Patients at least 60 years old undergoing GA
- Participants
- 947 patients · 11 randomised controlled trials (RCTs)
- Comparison
- Remimazolam vs propofol for GA
- Outcome
- Hypotension (postinduction and intra-operative)
Methodological detailstrial sequential analysis, sensitivity analysis, random effects model, subgroups and meta-regression
- Trial sequential analysis
- Sensitivity analysis
- Random effects model
- Subgroups and meta-regression
Pooled result
Postinduction and intra-operative hypotension
Relative risk
0.41
95% CI 0.27–0.62
P < 0.001
Remimazolam vs Propofol
RR 0.41 (95% CI 0.27–0.62); P < 0.001
As reported in the abstract
Further pooled results
| Outcome | P value |
|---|---|
| Heart rateHigher with remimazolam | P = 0.01 |
| Time to loss of consciousnessLonger with remimazolam | P < 0.001 |
| BIS at loss of consciousnessHigher with remimazolam | P = 0.04 |
MAP, emergence time, extubation time, emergence agitation
- No differences found
Safety
| Outcome | RR (95% CI) | P value | |
|---|---|---|---|
| Bradycardia | 0.58 (0.34–0.98) | P = 0.04 | |
| 0.20.5125Relative risk (log scale) |
| Outcome | P value |
|---|---|
| Injection painLower with remimazolam | P < 0.001 |
Original publication
Remimazolam vs. propofol for general anaesthesia in elderly patients: a meta-analysis with trial sequential analysis. Eur J Anaesthesiol. Published 12 August 2024. doi:10.
Composed by AI from the published abstract and checked against it. How Briefs are made →