Cardiothoracic & vascular anesthesia
REmoval of cytokines during CArdiac surgery (RECCAS): a randomised controlled trial
Authors' conclusion
HA did not reduce the IL-6 level on ICU admission or afterwards.
Study context
- Population
- Patients >65 years undergoing elective on-pump cardiac surgery
- Participants
- 38 patients
- Comparison
- Intraoperative haemoadsorption during cardiopulmonary bypass (CPB) vs standard care without haemoadsorption (HA)
- Standard caren = 19reference
- HAn = 19
- Primary endpoint
- Mean IL-6 serum concentration
- Follow-up
- ICU admission
Methodological detailsprospective
- Prospective
Primary result
As reported in the abstract
IL-6 serum concentration on ICU admission
- HA vs Standard care: P = 0.511
Secondary outcomes
Cardiac index · ICU day 2 · increased in HA
P = 0.012
Intraoperative pre- vs post-adsorber levels · During surgery
- IL-2, IL-6, IL-8, IL-10, heparan sulfate and myoglobin post-adsorber levels reduced
IL-6 on intensive care unit (ICU) day 1 and 2
- Did not differ between groups
SOFA scores, lactate, C-reactive protein, PCT
- No statistically significant differences
Fluid and fibrinogen requirements
- Lower fluid and fibrinogen requirements with HA
RRT
- Need for RRT did not differ; shorter duration with HA
Ventilation time, respiratory parameters, infectious complications, delirium, ICU and hospital LOS, mortality
- Did not differ between groups
Parts of this Brief are withheld: the automatic checks could not confirm them against the abstract.
Original publication
REmoval of cytokines during CArdiac surgery (RECCAS): a randomised controlled trial. Crit Care. Published 12 December 2024. doi:10.
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