Risk Factors for Acute Kidney Injury in Adult Patients Under Veno-Arterial Extracorporeal Membrane Oxygenation Support
Authors' conclusion
This study found a high incidence (53.3%) of AKI stage 3 in adult patients with VA-ECMO support and an association with increased in-hospital mortality. Concomitant hypertension, low pre-ECMO hemoglobin, and elevated pre-ECMO lactate and pre-ECMO creatinine were independent risk factors for AKI stage 3 in patients receiving VA-ECMO.
Study context
- Population
- Adults (≥18 years) on veno-arterial extracorporeal membrane oxygenation (VA-ECMO) support, Fuwai Hospital, January 2020 to December 2022
- Comparison
- Acute kidney injury (AKI) KDIGO stage 3 vs stage <3
- AKI stage 3n = 40
- Outcome
- Incidence of AKI stage 3 and independent risk factors (multivariate logistic regression)
Methodological detailssingle-centre, multivariate logistic regression
- Single-centre
- Multivariate logistic regression
Main finding
As reported in the abstract
Odds ratio (95% CI)P value
Concomitant hypertension
0.250(0.063–0.987)
P = 0.048Pre-ECMO hemoglobin
0.969(0.947–0.992)
P = 0.009Pre-ECMO lactate
1.173(1.028–1.339)
P = 0.018Pre-ECMO creatinine
1.014(1.003–1.025)
P = 0.011- Developed AKI stage 3: 40 enrolled patients
- 53.3%
Observational data: associations, not effects.
Further findings
In-hospital mortality
P = 0.004
Parts of this Brief are withheld: the automatic checks could not confirm them against the abstract.
Original publication
Risk Factors for Acute Kidney Injury in Adult Patients Under Veno-Arterial Extracorporeal Membrane Oxygenation Support. J Cardiothorac Vasc Anesth. Published 30 March 2024. doi:10.
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