Cardiothoracic & vascular anesthesia
Risk factors, outcomes, and early prediction of cardiac surgery-associated acute kidney injury: a post hoc subgroup analysis of the Epidemiology of Surgery Associated Acute Kidney Injury study
Authors' conclusion
Overall, 25% of cardiac surgery patients developed cardiac surgery-associated acute kidney injury, and 33% of these patients experienced persistent cardiac surgery-associated acute kidney injury, which was associated with poor outcomes.
Study context
- Population
- Patients undergoing cardiac surgery in the Epidemiology of Surgery Associated Acute Kidney Injury (EPIS-AKI) study
- Participants
- 3,101 cardiac surgery patients
- Primary endpoint
- CSA-AKI (AKI per KDIGO criteria) within 72 h after surgery; persistent CSA-AKI (lasting >48 h)
- Follow-up
- 72 h after surgery
Methodological detailsmultivariable logistic regression
- Multivariable logistic regression
Primary result
As reported in the abstract
CSA-AKI and persistent CSA-AKI
Cardiac surgery-associated acute kidney injury (CSA-AKI)
802
25.9%
Persistent CSA-AKI among CSA-AKI patients
279 of the 802
34.8%
Further findings
ICU and hospital mortality, persistent vs transient CSA-AKI
- Higher ICU and hospital mortality with persistent vs transient CSA-AKI
Risk score for predicting persistent CSA-AKI (EPIS CSA-AKI risk score)
- AUC
- 0.79 (95% CI 0.7355-0.8457)
Original publication
Risk factors, outcomes, and early prediction of cardiac surgery-associated acute kidney injury: a post hoc subgroup analysis of the Epidemiology of Surgery Associated Acute Kidney Injury study. Br J Anaesth. Published 9 October 2025. doi:10.
Composed by AI from the published abstract and checked against it. How Briefs are made →