Respiratory failure & ventilation
Role of diaphragmatic dysfunction in extubation failure among patients at high risk of reintubation: A prospective cohort study
Authors' conclusion
Diaphragm dysfunction could contribute to an elevated extubation failure rate.
Study context
- Population
- Adults intubated >24 h, ready for extubation, at high risk of extubation failure, ICU in China
- Participants
- 113 adults
- Exposure
- Diaphragm dysfunction vs no diaphragm dysfunction
- Diaphragm dysfunctionn = 63
- Outcome
- Extubation failure (reintubation or death)
- Follow-up
- Within the initial 7 days following extubation
Methodological detailssingle-centre
- Single-centre
Main finding
As reported in the abstract
Extubation failure (reintubation or death within 7 days) · 7 days
Extubation failure, all patients: 27 of 113
23.89 %
Diaphragm dysfunction associated with extubation failure, adjusted HR
4.56
95% CI 1.56–13.33
Observational data: associations, not effects.
Further findings
- Medical Research Council score associated with extubation failure, adjusted HR
- 0.93 (95% CI 0.88-0.99)
- Cox proportional hazards regression
Original publication
Role of diaphragmatic dysfunction in extubation failure among patients at high risk of reintubation: A prospective cohort study. J Crit Care. Published 10 December 2024. doi:10.
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