Cardiothoracic & vascular anesthesia
Safety of nonselective nonsteroidal anti-inflammatory drugs in cardiac surgery: a historical cohort study
Authors' conclusion
In patients who received nonselective NSAIDs early after cardiac surgery, the rate of AKI was lower than reported in literature, likely due to selection bias. Baseline renal function emerged as the most important factor, with low preoperative eGFR being the strongest predictor of AKI following NSAID administration.
Study context
- Population
- Adults undergoing cardiac surgery with sternotomy or thoracotomy (1 October 2020–30 September 2022) receiving nonselective nonsteroidal anti-inflammatory drugs (NSAIDs) postoperatively
- Participants
- 431 adults
- Outcome
- Proportion of patients developing AKI, MACE, or major bleeding during hospitalisation
- Follow-up
- Within 7 days of the NSAID exposure
Methodological detailssingle-centre
- Single-centre
Main finding
As reported in the abstract
AKI, MACE, major bleeding after NSAID administration
| Group | Value | Acute kidney injury (AKI) | Major adverse cardiovascular events (MACE) | Major bleeding |
|---|---|---|---|---|
| NSAIDs | 12% | 12% | 1% | 3% |
NSAIDs
Value12%
Acute kidney injury (AKI)12%
Major adverse cardiovascular events (MACE)1%
Major bleeding3%
Observational data: associations, not effects.
Further findings
Risk factors for AKI (machine learning)
- Older age; shorter height; history of stroke; low preoperative estimated glomerular filtration rate (eGFR) and hemoglobin; high preoperative platelet count, INR and blood urea nitrogen; reduced eGFR and platelet count before NSAID exposure
Safety
| Outcome | Values |
|---|---|
| AKI, MACE, major bleeding after NSAID administration · within 7 days of the NSAID exposure | NSAIDs AKI 12% · MACE 1% · Major bleeding 3% |
Original publication
Safety of nonselective nonsteroidal anti-inflammatory drugs in cardiac surgery: a historical cohort study. Can J Anaesth. Published 25 June 2025. doi:10.
Composed by AI from the published abstract and checked against it. How Briefs are made →