Cardiothoracic & vascular anaesthesia
Early postoperative non-steroidal anti-inflammatory drugs and anastomotic leakage after oesophagectomy
Main finding · Anastomotic leakageResult — go to the resultOdds ratio 1.04 95 per cent CI 0.97–1.10Authors' conclusion
Early postoperative NSAID use was not associated with anastomotic leakage or other complications in patients who underwent oesophagectomy.
Study context
- Population
- Patients who underwent oesophagectomy for cancer, July 2010–March 2019
- Participants
- 39,418 eligible patients
- Exposure
- Early postoperative non-steroidal anti-inflammatory drug (NSAID) use vs no NSAID use
- NSAIDsn = 16,211
- Outcome
- Anastomotic leakage
Methodological detailsJapanese nationwide inpatient database, stabilized inverse probability of treatment weighting (IPTW), propensity score matching, instrumental variable analyses
- Japanese nationwide inpatient database
- Stabilized IPTW
- Propensity score matching
- Instrumental variable analyses
Main finding
As reported in the abstract
Odds ratio
1.04
95 per cent CI 0.97–1.10
NSAIDs vs No NSAIDs
OR 1.04 (95 per cent CI 0.97–1.10)
- Anastomotic leakage overall
- 5729 (15 per cent)
Observational data: associations, not effects.
Secondary outcomes
30-day mortality and in-hospital mortality
- Did not differ according to NSAID use
Safety
AKI and gastrointestinal bleeding
- Did not differ according to NSAID use
Original publication
Early postoperative non-steroidal anti-inflammatory drugs and anastomotic leakage after oesophagectomy. Br J Surg. Published 26 November 2022. doi:10.
Composed by AI from the published abstract and checked against it. How Briefs are made →