Secondary Analysis of the Cancer and Anaesthesia (CAN) ‐Study, a Randomised Controlled Trial – Local Anaesthesia and Overall Survival
Authors' conclusion
We found no association with local-anaesthetic skin infiltration or regional anaesthesia and long-term survival in this non-preplanned secondary analysis of a randomised controlled trial.
Study context
- Population
- Breast cancer patients in the CAN study (sevoflurane vs propofol maintenance)analysed
- Participants
- 1,670 patients
- Comparison
- Any local or regional anaesthesia vs neither during breast cancer surgery
- Local anaesthetic infiltrationn = 803
- Paravertebral blockn = 67
- Bothn = 75
- Neithern = 725reference
- Primary endpoint
- Overall survival
- Follow-up
- Median 76.8 months
Methodological detailsexploratory, non-preplanned
- Exploratory
- Non-preplanned
Primary result
As reported in the abstract
- No significant differences in overall survival
- Any local or regional anaesthesia (n = 945) vs Neither: P = 0.54
- All four groups: P = 0.89
Original publication
Secondary Analysis of the CAN ‐Study, a Randomised Controlled Trial – Local Anaesthesia and Overall Survival. Acta Anaesthesiol Scand. Published 28 May 2026. doi:10.
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