Secondary infections in critically ill patients with viral pneumonia due to COVID-19 and influenza: a historical cohort study
Authors' conclusion
We found no difference in the incidence of SI between COVID-19 and influenza in our cohort study, but SI in patients with COVID-19 were associated with worse clinical outcomes and increased healthcare resource use.
Study context
- Population
- Critically ill intensive care unit (ICU) patients with viral pneumonia due to COVID-19 or seasonal influenza
- Participants
- 95 vs 47
- Exposure
- COVID-19 vs seasonal influenza viral pneumonia
- COVID-19n = 95
- Influenzan = 47reference
- Outcome
- Rate of secondary infections (SI)
Methodological detailstwo tertiary care centres
- Two tertiary care centres
Main finding
As reported in the abstract
COVID-19 vs InfluenzaEstimate (95% CI)
COVID-19
unadjusted OR 1.16(0.57–2.33)
Adjusted for baseline differences between cohorts; no significant difference
adjusted OR 1.00(0.41–2.44)
Observational data: associations, not effects.
Secondary outcomes
| Outcome | Steroids | No steroids |
|---|---|---|
| SI incidence in COVID-19 patients, steroids vs no steroids (subgroup) | 75% · 15 of 20 | 49% · 37 of 75 |
ICU and hospital LOS, duration of mechanical ventilation, COVID-19 patients with vs without secondary infections (SI) (subgroup)
- COVID-19 patients with SI had longer ICU and hospital stays and duration of mechanical ventilation
Original publication
Secondary infections in critically ill patients with viral pneumonia due to COVID-19 and influenza: a historical cohort study. Can J Anaesth. Published 14 March 2023. doi:10.
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