Sepsis Alert Systems, Mortality, and Adherence in Emergency Departments: A Systematic Review and Meta-Analysis
Pooled result · MortalityResult — go to the resultRelative risk 0.81 95% CI 0.71–0.91Authors' conclusion
These findings suggest that sepsis alert systems in EDs were associated with better patient outcomes along with better adherence to sepsis management protocols.
Study context
- Population
- Adult ED patients with sepsis
- Participants
- 19,580 patients · 22 studies
- Comparison
- Sepsis alert systems vs no alert system in emergency departments (EDs)
- Outcome
- Mortality, ICU admissions, hospital stay duration, and adherence to the sepsis bundle
Methodological detailsrandom-effects model, PRISMA
- Random-effects model
- PRISMA
Pooled result
Mortality
Relative risk
0.81
95% CI 0.71–0.91
Sepsis alert systems vs Control
RR 0.81 (95% CI 0.71–0.91)
As reported in the abstract
Further pooled results
| Outcome | SMD (95% CI) | |
|---|---|---|
| Length of hospital stay | −0.15 (−0.20 to −0.11) | |
| Time to fluid administration (sepsis bundle adherence) | −0.42 (−0.52 to −0.32) | |
| Time to blood culture (sepsis bundle adherence) | −0.31 (−0.40 to −0.21) | |
| Time to antibiotic administration (sepsis bundle adherence) | −0.34 (−0.39 to −0.29) | |
| Time to lactate measurement (sepsis bundle adherence) | −0.15 (−0.22 to −0.08) | |
| −1−0.500.5Difference (linear scale) |
Mortality, electronic alerts (subgroup)
| RR (95% CI) | ||
|---|---|---|
| Electronic alerts | 0.78 (0.67–0.92) | |
| 0.512Relative risk (log scale) |
Adherence with blood culture guidelines, electronic alerts (subgroup)
| RR (95% CI) | ||
|---|---|---|
| Electronic alerts | 1.14 (1.03–1.27) | |
| 0.512Relative risk (log scale) |
Original publication
Sepsis Alert Systems, Mortality, and Adherence in Emergency Departments: A Systematic Review and Meta-Analysis. JAMA Netw Open. Published 1 July 2024. doi:10.
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