Sepsis-induced hypocholesterolemia is linked to low cardiomyocyte membrane cholesterol and impaired catecholamine responsiveness
Authors' conclusion
In a long-term rat model of sepsis, that parallels changes seen in septic patients, cardiomyocyte membrane cholesterol fell with associated decreases in catecholamine responsiveness.
Study context
- Population
- Fluid-resuscitated rat model of fecal peritonitis, and septic patients on Days 1–3 of ICU admission
- Participants
- 27 septic patients
- Comparison
- Cholesterol infusion in septic rats; rat model vs septic patients
Methodological detailsfluid-resuscitated rat model of fecal peritonitis, comparison with septic patients
- Fluid-resuscitated rat model of fecal peritonitis
- Comparison with septic patients
Main finding
As reported in the abstract
- Fall in stroke volume, rise in heart rate, plasma troponin and BNP, and fall in plasma HDL-cholesterol on ICU Day 1 (patients) and at 6 h (rats) prognosticated poor outcomes
- Cardiomyocyte membrane cholesterol fell in rats, more so in poor prognosis animals, with blunted inotropic response to dobutamine
- Cholesterol administration restored cardiomyocyte membrane cholesterol, dobutamine responsiveness and adrenergic signaling
Original publication
Sepsis-induced hypocholesterolemia is linked to low cardiomyocyte membrane cholesterol and impaired catecholamine responsiveness. Crit Care. Published 25 September 2025. doi:10.
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