Sepsis mortality among patients with haematological malignancy admitted to intensive care 2000–2022: a binational cohort study
Authors' conclusion
Sepsis mortality has improved in patients with haematological malignancy admitted to ICU. However, mortality remains higher in patients with haematological malignancy than those without.
Study context
- Population
- Patients with a primary intensive care unit (ICU) admission diagnosis of sepsis, 216 intensive care units (ICUs) in Australia or New Zealand, January 2000–December 2022
- Participants
- 282,627 patients · 216 ICUs
- Exposure
- Haematological malignancy vs no haematological malignancy
- Haematological malignancyn = 17,313
- Outcome
- In-hospital mortality (annual crude and adjusted)
Methodological detailsbinational, multicentre
- Binational
- Multicentre
Main finding
As reported in the abstract
In-hospital sepsis mortality, 2000 vs 2021
Adjusted annual OR of in-hospital death (95% CI)P value
Haematological malignancy vs Without haematological malignancygreater reduction than without haematological malignancy
0.954(0.947–0.961)
P < 0.001Without haematological malignancy
0.968(0.966–0.971)
P < 0.001Observational data: associations, not effects.
Further findings
Risk factors for in-hospital mortality
- Leukopenia (white cell count < 1.0 × 109 cells/L) not associated with increased mortality in haematological malignancy
- P = 0.60
- Older age, higher SOFA score, comorbidities and mechanical ventilation associated with increased mortality
Original publication
Sepsis mortality among patients with haematological malignancy admitted to intensive care 2000–2022: a binational cohort study. Crit Care. Published 6 May 2024. doi:10.
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