Respiratory failure & ventilation
Serial electrical impedance tomography course in different treatment groups; The MaastrICCht cohort
Main finding · Optimal set PEEPResult — go to the resultDifference −1.4 cmH2O CI −2.6 to −0.2Authors' conclusion
Optimal and clinically applied PEEP were lower in the dexamethasone and dexamethasone + tocilizumab groups.
Study context
- Population
- Mechanically ventilated COVID-19 patients (MaastrICCht cohort)
- Exposure
- Dexamethasone vs No anti-inflammatory therapy
- Outcome
- Regional lung mechanics by electric impedance tomography (EIT) (dynamic compliance, alveolar overdistension and collapse) over admission
Methodological detailsserial electrical impedance tomography, linear mixed-effects models
- Serial electrical impedance tomography
- Linear mixed-effects models
Main finding
Optimal set PEEP
Difference
−1.4 cmH2O
CI −2.6 to −0.2
Dexamethasone vs No anti-inflammatory therapy
difference −1.4 cmH2O (CI −2.6 to −0.2)
As reported in the abstract
Observational data: associations, not effects.
Further findings
| Outcome | Difference (cmH2O) (CI) | |
|---|---|---|
| Clinically applied PEEPDexamethasone vs No anti-inflammatory therapy | −1.5 (−2.6 to −0.2) | |
| Clinically applied PEEPDexamethasone + tocilizumab vs No anti-inflammatory therapy | −2.2 (−5.1 to 0.6) | |
| −10−505Difference, cmH2O (linear scale) |
Original publication
Serial electrical impedance tomography course in different treatment groups; The MaastrICCht cohort. J Crit Care. Published 18 December 2023. doi:10.
Composed by AI from the published abstract and checked against it. How Briefs are made →