Serum proteomes and their prognostic values in sepsis patients admitted to a medical intensive care unit: a single-center study using SWATH-MS proteomics
Authors' conclusion
A novel set of biomarkers was identified in this study, including ACTB, FINC, CXCL7, TIMP1, and PF4, for assessing sepsis prognosis. The six-variable model incorporating SOFA scores demonstrated a high prognostic value for in-hospital mortality
Study context
- Population
- Adults with bacterial sepsis admitted to a medical ICU at a single tertiary hospital, January 2011–January 2020
- Participants
- 217 vs 292
- Exposure
- Sepsis vs Healthy controls
- Sepsisn = 217
- Healthy controlsn = 292reference
- Outcome
- Serum proteomic biomarkers for assessing sepsis severity and predicting outcomes (in-hospital mortality)
Methodological detailssingle-centre, SWATH-MS proteomics
- Single-centre
- SWATH-MS proteomics
Main finding
As reported in the abstract
Discrimination of sepsis subgroups and prediction of in-hospital mortality
- 5 proteins (ACTB, fibronectin (FINC), TIMP1, PF4, CXCL7) discriminated sepsis subgroups, AUC range
- 0.786 to 0.833
- Six-variable model (5 proteins + SOFA score) for in-hospital mortality, AUC
- 0.903
- Decreased FINC, in-hospital mortality (multivariable Cox), HR 0.88 (0.79-0.98)
- p = 0.024
- Higher SOFA scores, in-hospital mortality (multivariable Cox), HR 1.08 (1.03-1.13)
- p = 0.002
- Gram-negative sepsis, in-hospital mortality (multivariable Cox), HR 1.42 (1.02-1.97)
- p = 0.038
Observational data: associations, not effects.
Parts of this Brief are withheld: the automatic checks could not confirm them against the abstract.
Original publication
Serum proteomes and their prognostic values in sepsis patients admitted to a medical intensive care unit: a single-center study using SWATH-MS proteomics. Ann Intensive Care. Published 27 August 2025. doi:10.
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