Severe listeriosis in intensive care units: insights from a retrospective multicentric study
Authors' conclusion
Listeriosis requiring ICU admission is associated with high morbidity and mortality, particularly in older and immunocompromised patients.
Study context
- Population
- Intensive care unit (ICU) patients with culture-confirmed Listeria monocytogenes infection, 23 French hospitals over 10 years
- Participants
- 110 patients
- Outcome
- ICU mortality
Methodological detailsmulticentre
- Multicentre
Main finding
As reported in the abstract
ICU mortality rate
25%
Observational data: associations, not effects.
Further findings
| Outcome | OR (95% CI) | P value | |
|---|---|---|---|
| Factors associated with mortality in neurolisteriosis (subgroup)Each 1-point decrease in GCS at admission · multivariable logistic regression | 1.22 (1.05–1.45) | P = 0.009 | |
| 0.512Odds ratio (log scale) |
Factors associated with mortality in neurolisteriosis (subgroup)
| OR (95% CI) | P value | ||
|---|---|---|---|
| Higher CSF protein levelsMultivariable logistic regression | 1.56 (1.15–2.41) | P = 0.028 | |
| Steroid useNot significantly associated with reduced mortality · multivariable logistic regression | 0.30 (0.07–1.05) | P = 0.076 | |
| 0.050.21520Odds ratio (log scale) |
In-hospital mortality
- In-hospital mortality rate
- 32%
Organ support
- Invasive mechanical ventilation
- 58%
- Vasopressor support
- 44%
Original publication
Severe listeriosis in intensive care units: insights from a retrospective multicentric study. Crit Care. Published 19 May 2025. doi:10.
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