Sex- and Age-Related Differences in Post-Burn Pathophysiology
Main finding · Mortality, adults (< 60 yr)Result — go to the resultOdds ratio 3.6 95% CI 1.3–9.6Authors' conclusion
In this large cohort study, we observed that adult females show increased mortality compared with their male counterparts.
Study context
- Population
- Adult burn patients (≥18 yr) admitted with acute burn injury, 2006–2021
- Participants
- 2,321 patients
- Exposure
- Females vs males, by age group
- Outcome
- Mortality, adults (< 60 yr)
Methodological detailssingle-centre, tertiary burn center
- Single-centre
- Tertiary burn center
Main finding
As reported in the abstract
Odds ratio
3.6
95% CI 1.3–9.6
P < 0.05
By group
Female sex
OR 3.6 (95% CI 1.3–9.6); P < 0.05
Observational data: associations, not effects.
Further findings
Mortality and complications, older adults (≥60 yr)
- No differences between older adult males and females
Pro-inflammatory cytokines (interferon-γ, IL-6, IL-1β, tumor necrosis factor-α), adults
- Acute decreases in adult females
- P < 0.05
Inflammatory responses and organ function, older adults
- Similar inflammatory responses and limited differences in organ function between older adult males and females
Safety
- Increased skin graft loss in adult females vs adult males
- 5% vs. 9%; p < 0.05
Parts of this Brief are withheld: the automatic checks could not confirm them against the abstract.
Original publication
Sex- and Age-Related Differences in Post-Burn Pathophysiology. Crit Care Med. Published 17 July 2025. doi:10.
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