Sex differences in the Sequential Organ Failure Assessment (SOFA) score of ICU patients with sepsis or septic shock: a nationwide analysis
Authors' conclusion
Sex-specific differences exist in the SOFA score of patients admitted to a Swiss ICU with sepsis or septic shock, particularly in laboratory-based components.
Study context
- Population
- ICU patients with sepsis or septic shock admitted to 85 certified Swiss ICUs, 01/2021–12/202237% women
- Participants
- 5,078 patients
- Exposure
- Women vs men
- Outcome
- Total SOFA score
- Follow-up
- On admission
Methodological detailsprospectively enrolled, nationwide, multicentre (85 certified Swiss ICUs)
- Prospectively enrolled
- Nationwide
- Multicentre (85 certified Swiss ICUs)
Main finding
As reported in the abstract
P < 0.001
Observational data: associations, not effects.
Further findings
Total SOFA score, patients < 52 years (subgroup) · On admission
P = 0.004
ICU LOS
P = 0.13
ICU mortality
P = 0.17
SOFA components (coagulation, liver, renal) · On admission
- Difference driven by coagulation SOFA component
- P = 0.008
- Difference driven by liver SOFA component
- P < 0.001
- Difference driven by renal SOFA component
- P < 0.001
Original publication
Sex differences in the SOFA score of ICU patients with sepsis or septic shock: a nationwide analysis. Crit Care. Published 27 June 2024. doi:10.
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