Shock prediction with dipeptidyl peptidase-3 and renin (SPiDeR) in hypoxemic patients with COVID-19
Authors' conclusion
In patients hospitalized with COVID-19 and hypoxemia without baseline hypotension, higher baseline plasma levels of DPP3 but not renin were associated with increased risk of subsequent shock and death.
Study context
- Population
- Adults hospitalised with acute hypoxemia from COVID-19 without baseline vasopressor requirement
- Participants
- 184 adults
- Comparison
- Day 0 DPP3 and renin above vs below the median
- Primary endpoint
- Development of shock (initiation of vasopressor therapy)
- Follow-up
- Day 28
Methodological detailsbiomarker study
- Biomarker study
Primary result
As reported in the abstract
Vasopressor initiation · 28 days
P = 0.031
Further findings
28-day mortality
P < 0.001
28-day mortality
- After adjustment, DPP3 above median associated with greater 28-day mortality, fewer vasopressor-free days and greater odds of a hypotensive event over 7 days
Parts of this Brief are withheld: the automatic checks could not confirm them against the abstract.
Original publication
Shock prediction with dipeptidyl peptidase-3 and renin (SPiDeR) in hypoxemic patients with COVID-19. J Crit Care. Published 14 November 2024. doi:10.
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