Hemodynamics, fluids & transfusion
Should Cell Salvage Be Used in Liver Resection and Transplantation? A Systematic Review and Meta-analysis
Pooled result · Allogeneic RBC transfusion, liver transplantResult — go to the resultMean difference −1.81 95% CI −3.22 to −0.40Authors' conclusion
IBSA may reduce intraoperative allogeneic RBC transfusion without compromising oncologic outcomes.
Study context
- Population
- Patients undergoing liver resection or transplantation
- Participants
- 3,433 patients · 21 observational studies
- Comparison
- IBSA vs control in liver surgery
- Outcome
- Intraoperative allogeneic RBC transfusion (proportion of patients and volume transfused)
Methodological detailsrandom effects models, transplant and resection analysed separately, 16 transplant, 5 resection studies; 17 incorporated oncologic indications
- Random effects models
- Transplant and resection analysed separately
- 16 transplant, 5 resection studies; 17 incorporated oncologic indications
Pooled result
Allogeneic RBC transfusion, liver transplant
Mean difference
−1.81
95% CI −3.22 to −0.40
P = 0.01
IBSA vs Control
mean difference −1.81 (95% CI −3.22 to −0.40); P = 0.01
As reported in the abstract
Further pooled results
Overall survival, liver transplant
- No significant difference in overall survival in liver transplant (HR)
- 1.12 (0.75, 1.68)
- P =0.59
- I 2 =0%
Disease-free survival, liver transplant
- No significant difference in disease-free survival in liver transplant (HR)
- 0.93 (0.57, 1.48)
- P =0.75
- I 2 =0%
Overall survival, liver resection
- No significant difference in overall survival in liver resection (HR)
- 0.69 (0.45, 1.05)
- P =0.08
- I 2 =0%
Disease-free survival, liver resection
- No significant difference in disease-free survival in liver resection (HR)
- 0.93 (0.59, 1.45)
- P =0.74
- I 2 =0%
Allogeneic red blood cell (RBC) transfusion, liver resection
- Few resection studies reported on transfusion for meta-analysis
Original publication
Should Cell Salvage Be Used in Liver Resection and Transplantation? A Systematic Review and Meta-analysis. Ann Surg. Published 21 July 2022. doi:10.
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