Single-nuclei RNA Profiling Reveals Disruption of Adipokine and Inflammatory Signaling in Adipose Tissue of Burn Patients
Authors' conclusion
We provide novel insight toward the effect of burns on adipokine release, inflammatory signaling pathways, and adipose heterogeneity over the trajectory of acute and chronic stages.
Study context
- Population
- Severely burned adult patients during acute hospitalization (plasma and subcutaneous adipose tissue samples at various time points)
Methodological detailssingle-nuclei RNA sequencing, RT-qPCR
- Single-nuclei RNA sequencing
- RT-qPCR
Main finding
As reported in the abstract
- Systemic inflammation and adrenergic stress increase IL-6 signaling, lipolysis, browning and adipokine dysfunction in adipose tissue of adult burn patients
- First comprehensive characterization by single-nuclei RNA sequencing of alterations in the adipose tissue microenvironment at acute and chronic stages postburn
Observational data: associations, not effects.
Original publication
Single-nuclei RNA Profiling Reveals Disruption of Adipokine and Inflammatory Signaling in Adipose Tissue of Burn Patients. Ann Surg. Published 14 April 2023. doi:10.
Composed by AI from the published abstract and checked against it. How Briefs are made →