Respiratory failure & ventilation
Solid-state esophageal pressure sensor for the estimation of pleural pressure: a bench and first-in-human validation study
Authors' conclusion
The novel solid-state pressure transducer showed good accuracy on the bench, in healthy volunteers and in ventilated ICU-patients.
Study context
- Population
- Bench setup (5 days), spontaneously breathing healthy volunteers and mechanically ventilated ICU patients15 volunteers · 16 ICU patients
- Comparison
- Solid-state esophageal pressure transducer vs balloon catheter
- Outcome
- Agreement of Pes measurements (bias and upper and lower limits of agreement, Pessolid - Pesbal); non-inferiority hypothesised
Methodological detailsbench and first-in-human validation, Bland-Altman analysis with mixed effects modelling and bootstrapping
- Bench and first-in-human validation
- Bland-Altman analysis with mixed effects modelling and bootstrapping
Performance
As reported in the abstract
Agreement of solid-state Pes (Pessolid) vs balloon catheter Pes (Pesbal): bias (Pessolid - Pesbal) [upper LoA; lower LoA]
- Bench: positive bias (Psolid - Pref) for absolute minimal and maximum pressures, cmH2O
- around 1
- Healthy volunteers, end-expiratory pressure (Pes), cmH2O
- 1.59 [8.21; - 5.02]
- Healthy volunteers, end-inspiratory Pes, cmH2O
- - 2.32 [4.27; - 8.92]
- Healthy volunteers, ΔPes, cmH2O
- 3.91 [11.04; - 3.23]
- ICU patients, end-expiratory Pes, controlled/assisted ventilation, cmH2O
- - 0.15 [1.41; - 1.72]/- 0.19 [5.23; - 5.62]
- ICU patients, end-inspiratory Pes, controlled/assisted ventilation, cmH2O
- 0.32 [3.45; - 2.82]/- 0.54 [4.81; - 5.90]
- ICU patients, ΔPes, controlled/assisted ventilation, cmH2O
- 0.47 [3.90; - 2.96]/0.35 [4.01; - 3.31]
- ICU patients: Limits of agreement (LoA) for static measurements on controlled ventilation
- ≤ 2cmH2O
Original publication
Solid-state esophageal pressure sensor for the estimation of pleural pressure: a bench and first-in-human validation study. Crit Care. Published 27 January 2025. doi:10.
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