Cardiothoracic & vascular anesthesia
Standard versus High Cardiopulmonary Bypass Flow Rate: A Randomized Controlled Subtrial Comparing Brain Injury Biomarker Release
Authors' conclusion
An increased flow rate did not have any significant effects on biomarker levels compared to a standard flow rate.
Study context
- Population
- Patients undergoing elective cardiac surgery with cardiopulmonary bypass (CPB), Sahlgrenska University Hospital, Sweden
- Participants
- 40 patients
- Comparison
- High vs standard CPB flow rate
- Primary endpoint
- Brain injury biomarker release (plasma glial fibrillary acidic protein, neurofilament light chain, total-tau, phosphorylated-tau217)
- Follow-up
- Before anesthesia induction, after 60 minutes on CPB, and at 30 minutes, 24 hours, and 72 hours post-CPB
Methodological detailssubstudy
- Substudy
Primary result
As reported in the abstract
Brain injury biomarker levels
- No differences between the 2 flow rate groups
- Mixed models for repeated measures
Further findings
Postoperative delirium
- No difference in occurrence between the 2 groups
Associations with biomarker levels
- Age associated with increased neurofilament light chain levels
- Female sex associated with lower biomarker levels
- Oxygen delivery >330 mL/min/m² associated with lower biomarker levels
- Near-infrared spectroscopy level >60% associated with lower biomarker levels
Original publication
Standard versus High Cardiopulmonary Bypass Flow Rate: A Randomized Controlled Subtrial Comparing Brain Injury Biomarker Release. J Cardiothorac Vasc Anesth. Published 14 July 2024. doi:10.
Composed by AI from the published abstract and checked against it. How Briefs are made →