Stratifying risk in ACLF-3 patients: The impact of circulatory and respiratory failure on one-year post-transplant outcomes
Main finding · One-year post-LT mortalityResult — go to the resultHazard ratio 1.32 95 % CI 1.08–1.62Authors' conclusion
Specific OF combinations affect post-LT outcomes in ACLF-3 patients. Combined respiratory and circulatory failure at LT time was associated with poorer outcomes, regardless of the number of OF.
Study context
- Population
- Patients with ACLF grade 3 undergoing liver transplant, US Scientific Registry of Transplant Recipients
- Participants
- 5,054 patients
- Exposure
- Circulatory + respiratory vs Circulatory + other organ failures (OF)
- Circulatory + other OFn = 427reference
- Circulatory + respiratoryn = 1,042
- Other OFn = 3,357
- Outcome
- Mortality
- Follow-up
- One-year post-LT
Methodological detailsUS Scientific Registry of Transplant Recipients
- US Scientific Registry of Transplant Recipients
Main finding
One-year post-LT mortality · one-year
Hazard ratio
1.32
95 % CI 1.08–1.62
P < 0.01
Circulatory + respiratory vs Circulatory + other OF
HR 1.32 (95 % CI 1.08–1.62); P < 0.01
As reported in the abstract
- Overall died within one-year post-LT
- 14 %(728/5054)
Observational data: associations, not effects.
Further findings
| Outcome | OR (95 % CI) | P value | |
|---|---|---|---|
| Poor functional status · one-yearOther OF vs Circulatory + other OF | 0.73 (0.54–0.98) | P < 0.01 | |
| 0.512Odds ratio (log scale) |
Original publication
Stratifying risk in ACLF-3 patients: The impact of circulatory and respiratory failure on one-year post-transplant outcomes. J Crit Care. Published 30 May 2025. doi:10.
Composed by AI from the published abstract and checked against it. How Briefs are made →