Respiratory failure & ventilation
Subphenotypes in acute respiratory distress syndrome: A scoping review across clinical, biological, computational, imaging, omics, and artificial intelligence approaches
Authors' conclusion
ARDS subphenotypes-particularly hyperinflammatory and hypoinflammatory classes-are prognostically meaningful and associated with heterogeneity of treatment effect. Parsimonious clinical and computational classifiers appear closest to bedside translation.
Study context
- Population
- Adults with acute respiratory distress syndrome (ARDS); original studies deriving, applying, or validating ARDS phenotypes/subphenotypes (January 2013-December 31, 2025)60 studies
- Comparison
- Hyperinflammatory vs Hypoinflammatory
- Outcome
- ARDS subphenotypes
Main finding
As reported in the abstract
- Subphenotypes reported across clinical, biological, computational, imaging, omics and artificial intelligence (AI) domains, with uneven evidence maturity
- Reproducibility and validation strongest in biological and computational frameworks; imaging and omics evidence more heterogeneous and less often externally validated
- Most robust distinction: hyperinflammatory vs hypoinflammatory groups, differing in mortality, ventilator-free days and organ failure
- Heterogeneity of treatment effect in secondary analyses of RCTs (fluid management, statins, corticosteroids, recruitment manoeuvres)
- Clinical and computational approaches provided parsimonious classifiers for near real-time assignment
- Biological studies implicated inflammatory, epithelial and endothelial injury markers
- AI models integrated multimodal data and reproduced known phenotypes; external validation and interpretability inconsistent
Original publication
Subphenotypes in acute respiratory distress syndrome: A scoping review across clinical, biological, computational, imaging, omics, and artificial intelligence approaches. J Crit Care. Published 30 January 2026. doi:10.
Composed by AI from the published abstract and checked against it. How Briefs are made →