Temporary mechanical support in fulminant myocarditis: prognostic factors and clinical implications from the FULLMOON study
Authors' conclusion
Despite a relatively young cohort, FM requiring t-MCS is associated with a high 1-year mortality rate.
Study context
- Population
- Adults with suspected fulminant myocarditis treated with V-A ECMO and/or Impella, FULLMOON cohort (36 centres, 15 countries)of 419 in cohort
- Participants
- 295 adults
- Exposure
- Timing of endomyocardial biopsy: early vs delayed vs none
- Outcome
- Mortality, HTx or LVAD
- Follow-up
- 1 year
Methodological detailsinternational multicentre cohort, propensity score-weighted analysis, multivariate Cox regression
- International multicentre cohort
- Propensity score-weighted analysis
- Multivariate Cox regression
Main finding
As reported in the abstract
1-year mortality, HTx or LVAD
Hazard ratio (95% CI)P value
Delayed EMB vs Early EMB
1.55(1.23–1.96)
P < 0.01Delayed EMB vs No EMB
1.59(1.26–2.01)
P < 0.01Early EMB vs No EMBevent-free survival did not differ significantly
1.03(0.80–1.32)
P = 0.85- Death, HTx or left-ventricular assist device (LVAD), whole cohort
- 44%
Observational data: associations, not effects.
Further findings
1-year mortality, whole cohort
- One-year mortality
- 36%
Myocarditis confirmed by histology or cardiac MRI
- Confirmed
- 204 (69%)
Original publication
Temporary mechanical support in fulminant myocarditis: prognostic factors and clinical implications from the FULLMOON study. Intensive Care Med. Published 12 January 2026. doi:10.
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