Respiratory failure & ventilation
The effect of culture on the benefits of awake prone positioning for adults with COVID-19 acute respiratory distress syndrome: A systematic review and meta-analysis
Pooled result · IntubationResult — go to the resultRelative risk 0.80 95% CI 0.72–0.90Authors' conclusion
APP reduces the risk of intubation and mortality, but the significance of this benefit varies with the cultural context.
Study context
- Population
- Adults with COVID-19-related acute respiratory distress syndrome (ARDS) or acute hypoxaemic respiratory failure
- Participants
- 3,615 adults · 22 randomised controlled trials (RCTs)
- Comparison
- Awake prone positioning vs standard care
- Outcome
- Intubation
Methodological detailssubgroup analysis by national Power Distance Index
- Subgroup analysis by national Power Distance Index
Pooled result
As reported in the abstract
Relative risk
0.80
95% CI 0.72–0.90
APP vs Standard care
RR 0.80 (95% CI 0.72–0.90)
Further pooled results
| Outcome | RR (95% CI) | |
|---|---|---|
| Mortality | 0.86 (0.74–0.99) | |
| 0.512Relative risk (log scale) |
| Outcome | APP | Standard care |
|---|---|---|
| Intubation, nations with PDI ≥80 (subgroup) | 21.2% · n = 508 | 32.3% · n = 512 |
| Intubation, nations with PDI <80 (subgroup) | 17.1% · n = 1084 | 20.1% · n = 1012 |
- Intubation, nations with Power Distance Index (PDI) ≥80 (subgroup) — Effects greater in nations with PDI at least 80: RR
- 0.67 (0.54 to 0.82) (95% CI)
- Intubation, nations with PDI <80 (subgroup) — Equipoise in nations with PDI less than 80: RR
- 0.89 (0.75 to 1.05) (95% CI)
Fidelity of awake prone positioning (APP) (adherence to recommended duration), PDI ≥80 vs <80
- Higher in nations with PDI at least 80
- P = 0.04
Original publication
The effect of culture on the benefits of awake prone positioning for adults with COVID-19 acute respiratory distress syndrome: A systematic review and meta-analysis. Eur J Anaesthesiol Intensive Care. Published 5 February 2025. doi:10.
Composed by AI from the published abstract and checked against it. How Briefs are made →