Respiratory failure & ventilation
The effects of prolonged prone positioning on response and prognosis in patients with acute respiratory distress syndrome: a retrospective cohort study
Main finding · 28-day mortalityResult — go to the resultHazard ratio 0.53 95% CI 0.32–0.85Authors' conclusion
PPP (≥ 16 h) is associated with reduced 28-day mortality and improved response rates in ICU patients with ARDS, without increasing complication risks.
Study context
- Population
- Acute respiratory distress syndrome (ARDS) patients in the intensive care unit (ICU) receiving prone positioning, Nanfang hospital of Southern Medical University
- Participants
- 234 patients · 81 matched pairs
- Exposure
- Prolonged vs standard prone positioning
- Prolonged prone positioning (PPP)n = 81
- Standard prone positioning (SPP)n = 81reference
- Outcome
- 28-day mortality
- Follow-up
- 28 days
Methodological detailspropensity-score matched, single-centre
- Propensity-score matched
- Single-centre
Main finding
As reported in the abstract
Hazard ratio
0.53
95% CI 0.32–0.85
P = 0.033
By group
PPP vs SPP
HR 0.53 (95% CI 0.32–0.85); P = 0.033
Observational data: associations, not effects.
Further findings
| Outcome | PPP | SPP | OR (95% CI) | P value | |
|---|---|---|---|---|---|
| Prone positioning response rate | 70.5% | 60.5% | 1.46 (1.23–1.89) | P = 0.025 | |
| 0.512Odds ratio (log scale) |
ICU and hospital LOS
- No significant association between PPP and reduced ICU or hospital LOS
Prone duration dose-response (restricted cubic spline (RCS))
- Gradual decrease in 28-day mortality with increasing prone duration; longer duration associated with higher likelihood of prone response
Safety
Prone ventilation-related complications
- No significant differences between the two groups
Original publication
The effects of prolonged prone positioning on response and prognosis in patients with acute respiratory distress syndrome: a retrospective cohort study. J Intensive Care. Published 7 May 2025. doi:10.
Composed by AI from the published abstract and checked against it. How Briefs are made →