The Efficacy of Glutamine Supplementation in Severe Adult Burn Patients: A Systematic Review With Trial Sequential Meta-Analysis
Pooled resultResult — go to the resultRelative risk 0.65 95% CI 0.33–1.28Authors' conclusion
Glutamine supplementation, regardless of administration, does not appear to improve clinical outcomes in severely adult burned patients.
Study context
- Population
- Severe adult burn patients
- Participants
- 1,577 patients · 10 randomized controlled trials (RCTs)
- Comparison
- Glutamine supplementation vs control
- Outcome
- Overall mortality
Methodological detailsrandom effects, trial sequential analysis
- Random effects
- Trial sequential analysis
Pooled result
As reported in the abstract
Relative risk
0.65
95% CI 0.33–1.28
P = 0.21
Glutamine vs Control
RR 0.65 (95% CI 0.33–1.28); P = 0.21
Further pooled results
| Outcome | RR (95% CI) | P value | |
|---|---|---|---|
| Infectious complications | 0.83 (0.63–1.09) | P = 0.18 | |
| 0.512Relative risk (log scale) |
Other secondary outcomes
- No significant effect of glutamine
Subgroups by administration route or burn severity (subgroup)
- No significant effects
Mortality and infectious complications, single- vs multicentre RCTs (subgroup)
- Significant subgroup effect: glutamine reduced mortality and infectious complications in single-centre RCTs but not in multicentre RCTs
- Trial sequential analyses (TSA): pooled single-centre results were type 1 errors; further trials would be futile
Original publication
The Efficacy of Glutamine Supplementation in Severe Adult Burn Patients: A Systematic Review With Trial Sequential Meta-Analysis. Crit Care Med. Published 28 April 2023. doi:10.
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