Cardiothoracic & vascular anesthesia

The haemodynamic effects of phenylephrine after cardiac surgery

Acta Anaesthesiol ScandPublished Mechanistic study

Main finding · Haemodynamic effects of phenylephrineResult — go to the resultMedian Δcardiac output 0.25 L/min

Authors' conclusion

In haemodynamically stable patients after cardiac surgery, phenylephrine increased PVR and SVR, but did not change the PVR/SVR ratio. Phenylephrine increased biventricular filling pressures and left ventricular end-diastolic area. Consequently, CO increased as ejection fraction was maintained.

Study context

Population
Patients in steady state after low-risk cardiac surgery
Participants
30 patients
Comparison
Baseline vs Phenylephrine
Outcome
Haemodynamic effects of phenylephrine

Main finding

As reported in the abstract

Median Δcardiac output

0.25 L/min

P = 0.012

By group

Ratio of systemic to pulmonary artery resistances not significantly changed
P = 0.59

Original publication

The haemodynamic effects of phenylephrine after cardiac surgery. Acta Anaesthesiol Scand. Published 25 April 2023. doi:10.1111/aas.14256

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