Cardiac arrest & resuscitation
The impact of comorbidity burden on cardiac arrest mortality: A population-based cohort study
Authors' conclusion
Comorbidity burden interacted with cardiac arrest to increase mortality beyond that explained by their separate effects.
Study context
- Population
- Adults hospitalised for cardiac arrest in Denmark, 1996–2021matched cohort
- Exposure
- Cardiac arrest vs matched general population, by comorbidity burden
- Outcome
- Mortality by comorbidity burden (none, low, moderate, severe) and biological interaction (interaction contrast)
- Follow-up
- 30 days
Methodological detailsnationwide, 5:1 matched comparison cohort
- Nationwide
- 5:1 matched comparison cohort
Main finding
As reported in the abstract
30-day mortality rate per 1,000 person-years, by comorbidity burden
Hazard ratio
1,435
no comorbidity burden
Hazard ratio
504
low comorbidity burden
Interaction contrast
2,145
low comorbidity burden
- Mortality rate explained by interaction, low comorbidity burden
- 11%
- Mortality rate explained by interaction, moderate comorbidity burden
- 20%
- Mortality rate explained by interaction, severe comorbidity burden
- 28%
Observational data: associations, not effects.
Further findings
Mortality rate explained by interaction, 31-365-day follow-up
- Low comorbidity burden
- 28%
- Moderate comorbidity burden
- 38%
- Severe comorbidity burden
- 41%
Interaction by cardiac arrest setting (OHCA and in-hospital)
- Interaction effect present for both OHCA and in-hospital cardiac arrest
Original publication
The impact of comorbidity burden on cardiac arrest mortality: A population-based cohort study. Resuscitation. Published 3 August 2024. doi:10.
Composed by AI from the published abstract and checked against it. How Briefs are made →