Perioperative medicine & outcomes
The impact of preoperative malnutrition on postoperative delirium: a systematic review and meta-analysis
Pooled result · PODResult — go to the resultOdds ratio 2.32 95% CI 1.62–3.32Authors' conclusion
Based on the currently available evidence, our results suggested that preoperative malnutrition was independently associated with POD in adult surgical patients.
Study context
- Population
- Adult surgical patients
- Participants
- 2,701 patients · 7 prospective cohort studies
- Comparison
- Preoperative malnutrition vs normal nutritional status
- Outcome
- POD
Methodological detailsrandom-effects model, subgroup analyses, Study quality by Newcastle-Ottawa scale; Newcastle-Ottawa scale (NOS) score above 7 points in all 7 studies
- Random-effects model
- Subgroup analyses
- Study quality by Newcastle-Ottawa scale; NOS score above 7 points in all 7 studies
Pooled result
As reported in the abstract
Odds ratio
2.32
95% CI 1.62–3.32
Malnutrition vs Normal nutritional status
OR 2.32 (95% CI 1.62–3.32)
Further pooled results
| Outcome | OR (95% CI) | P value | |
|---|---|---|---|
| POD, noncardiac surgery (subgroup) | 3.04 (1.99–4.62) | P < 0.001 | |
| POD, cardiac surgery (subgroup) | 1.76 (0.96–3.22) | P = 0.07 | |
| POD, MNA-SF assessment (subgroup) | 3.04 (1.99–4.62) | P < 0.001 | |
| POD, other assessment tools (subgroup) | 1.76 (0.96–3.22) | P = 0.07 | |
| 0.20.5125Odds ratio (log scale) |
Prevalence of preoperative malnutrition
- Pooled prevalence of preoperative malnutrition (408/2701)
- 15.1%
Postoperative delirium (POD) incidence
- POD occurred in 428 patients
- 15.8%
Other subgroups (POD instrument, study location, article quality)
- Association not significantly affected by POD evaluation instrument, study location or article quality (as printed: all P < 0.05)
Original publication
The impact of preoperative malnutrition on postoperative delirium: a systematic review and meta-analysis. Perioper Med (Lond). Published 26 October 2023. doi:10.
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