The posterior dominant rhythm: an electroencephalographic biomarker for cognitive recovery after general anaesthesia
Authors' conclusion
The temporal trajectory of the PDR peak frequency could be a useful perioperative marker for tracking cognitive dysfunction on the order of hours after surgery, particularly for cognitive domains of working memory, visuomotor speed, and executive function.
Study context
- Population
- Adult volunteers
- Participants
- 60 volunteers
- Comparison
- 3 h isoflurane GA vs resting wakefulness
Methodological detailssubstudy, mixed-effects models
- Substudy
- Mixed-effects models
Primary result
As reported in the abstract
PDR peak frequency (change from pre-intervention baseline)
Control
0.02
median difference · IQR 0.20 · Hz
Isoflurane
0.88
median difference · IQR 0.65 · Hz
- Control: Posterior dominant rhythm (PDR) peak frequency stable over several hours
- P = 0.39
- Isoflurane: PDR peak frequency initially reduced at return of responsiveness (ROR)
- P < 0.001
- PDR peak frequency recovery rate after isoflurane GA
- 0.20 Hz h-1
Further findings
Correlation of PDR peak frequency with cognitive performance after ROR
- PDR peak frequency correlated with reaction time and accuracy on multiple cognitive tasks
- P < 0.001
Original publication
The posterior dominant rhythm: an electroencephalographic biomarker for cognitive recovery after general anaesthesia. Br J Anaesth. Published 17 February 2022. doi:10.
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