The Role of Cell Cycle Arrest Biomarkers for Predicting Acute Kidney Injury in Critically Ill COVID-19 Patients: A Multicenter, Observational Study
Authors' conclusion
Urinary (TIMP-2) × (IGFBP7) predicts the occurrence of AKI in critically ill patients with COVID-19-associated ARDS.
Study context
- Population
- Critically ill patients with moderate or severe COVID-19-associated acute respiratory distress syndrome (ARDS), 12 centres across Europe and UK39 met primary endpoint
- Participants
- Three hundred patients
- Outcome
- Moderate or severe acute kidney injury (AKI) (Kidney Disease: Improving Global Outcomes definition)
Methodological detailsmulticentre, diagnostic/predictive accuracy
- Multicentre
- Diagnostic/predictive accuracy
Main finding
As reported in the abstract
Prediction of moderate or severe AKI · At enrollment
| Group | AUC |
|---|---|
| (TIMP-2) × (IGFBP7) | 0.89 (95% CI, 0.84-0.93) |
(TIMP-2) × (IGFBP7)
AUC0.89 (95% CI, 0.84-0.93)
Observational data: associations, not effects.
Further findings
(TIMP-2) × (IGFBP7) levels, endpoint-positive vs endpoint-negative · At enrollment and at 12 hours
- Significantly higher in endpoint-positive patients at enrollment and at 12 hours
Original publication
The Role of Cell Cycle Arrest Biomarkers for Predicting Acute Kidney Injury in Critically Ill COVID-19 Patients: A Multicenter, Observational Study. Crit Care Med. Published 28 March 2023. doi:10.
Composed by AI from the published abstract and checked against it. How Briefs are made →