Urinary biomarkers IGFBP7 and TIMP-2 in the Intensive Care Unit (ICU): a multicenter prospective study on acute kidney injury outcomes
Authors' conclusion
TIMP-2·IGFBP7 showed modest performance for early AKI detection, identifying RRT requirements and risk stratification in critically ill patients. While moderately effective for predicting outcomes, its role in differentiating transient from persistent AKI remains inconsistent.
Study context
- Population
- ICU patients from five hospitals in Barcelona, Spain
- Participants
- 455 patients · 5 hospitals
- Exposure
- High TIMP-2·IGFBP7 vs lower values at ICU admission
- Outcome
- AKI risk and AKI subtype (transient vs persistent; KDIGO criteria)
- Follow-up
- First seven days of ICU admission
Main finding
As reported in the abstract
High TIMP-2·IGFBP7Odds ratio (95% CI)P value
AKI
19.44(2.57–146.5)
P = 0.004Persistent AKI
4.3(1.61–11.41)
P = 0.003- Acute kidney injury (AKI) occurred
- 51%
- Transient AKI
- 29%
- Persistent AKI
- 71%
Observational data: associations, not effects.
Secondary outcomes
Renal replacement therapy (RRT) requirement
| OR (95% CI) | P value | ||
|---|---|---|---|
| High TIMP-2·IGFBP7 | 3.93 (1.34–11.47) | P = 0.012 | |
| 0.050.21520Odds ratio (log scale) |
ICU outcomes
- High TIMP-2·IGFBP7: longer ICU stays, more severe AKI, increased RRT duration, higher mortality
- TIMP-2·IGFBP7 correlated positively with ICU and in-hospital mortality and reduced 90-day survival
Original publication
Urinary biomarkers IGFBP7 and TIMP-2 in the ICU: a multicenter prospective study on acute kidney injury outcomes. Ann Intensive Care. Published 6 July 2026. doi:10.
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