Therapeutic efficacy of intravenous lidocaine infusion compared with thoracic epidural analgesia in major abdominal surgery: a noninferiority randomised clinical trial
Primary resultResult — go to the resultDifference 0.53 95% CI 0.0–1.0Authors' conclusion
Intravenous lidocaine is noninferior to thoracic epidural analgesia for acute postoperative pain control in major abdomial surgery at 24 h postoperatively.
Study context
- Population
- Patients undergoing open major abdominal surgery
- Participants
- 210 patients
- Comparison
- IV lidocaine vs thoracic epidural bupivacaine with morphine
- Primary endpoint
- Dynamic pain (numerical pain rating scale, NPR)
- Follow-up
- 24 h after surgery
Methodological detailsnoninferiority
- Noninferiority
Primary result
As reported in the abstract
24 h
Difference
0.53
95% CI 0.0–1.0
By group
Lidocaine
5.7
unspecified 1.8
Epidural
5.2
unspecified 1.9
Lidocaine vs Epidural
difference 0.53 (95% CI 0.0–1.0)
Non-inferiority margin 1 as printed, not drawn
Further findings
| Outcome | Average difference (mg) (95% CI) | |
|---|---|---|
| Morphine consumption · first 24 h | 1.8 (1–3) | |
| −2024Difference, mg (linear scale) |
Safety
Adverse events or complications associated with the procedures
- No differences found
Original publication
Therapeutic efficacy of intravenous lidocaine infusion compared with thoracic epidural analgesia in major abdominal surgery: a noninferiority randomised clinical trial. Br J Anaesth. Published 26 September 2023. doi:10.
Composed by AI from the published abstract and checked against it. How Briefs are made →