Thromboembolic complications were not different between intravenous and epidural analgesia after unilateral knee arthroplasty under neuraxial anesthesia: a propensity-score matched analysis
Main findingResult — go to the resultOdds ratio 1.88 95% CI 0.89–10.57Authors' conclusion
In this retrospective analysis, the incidence of TE complications after TKA under neuraxial anesthesia was not significantly different between intravenous and epidural analgesia.
Study context
- Population
- Patients undergoing unilateral total knee arthroplasty (TKA) under neuraxial anesthesia, tertiary hospital, 2016–2022matched cohort
- Participants
- 1,244 patients
- Exposure
- Epidural PCA after combined spinal-epidural (CSE) anaesthesia vs intravenous patient-controlled analgesia (IV-PCA) after spinal anaesthesia
- SA-IVn = 321reference
- CSE-En = 214
- Outcome
- Composite in-hospital thromboembolic (TE) events:
- MI
- Stroke
- Peripheral artery occlusion
- PE
- DVT
Methodological detailspropensity-score matched, single tertiary hospital
- Propensity-score matched
- Single tertiary hospital
Main finding
As reported in the abstract
Odds ratio
1.88
95% CI 0.89–10.57
P = 0.08
Events by group
CSE-E vs SA-IV
OR 1.88 (95% CI 0.89–10.57); P = 0.08
Observational data: associations, not effects.
Secondary outcomes
| Outcome | SA-IV | CSE-E | P value |
|---|---|---|---|
| Pain score after TKASignificantly lower in CSE-E | 5 (range 3–6) | 3 (range 2–5) | P < 0.001 |
Days to joint exercise initiation
- Higher in the CSE-E group
Safety
| Outcome | OR (95% CI) | P value |
|---|---|---|
| Transient motor weaknessMore frequent in CSE-E | 2.70 (9.27–451.78) | P < 0.001 |
General complications, delirium, falls, bedsores
- No differences
Original publication
Thromboembolic complications were not different between intravenous and epidural analgesia after unilateral knee arthroplasty under neuraxial anesthesia: a propensity-score matched analysis. Perioper Med (Lond). Published 17 January 2026. doi:10.
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