Thrombosis-Related Loss of Arterial Lines in the First Wave of COVID-19 and Non–COVID-19 Intensive Care Unit Patients
Main findingResult — go to the resultAdjusted subdistribution hazard ratio 2.18 95% CI 1.06–4.46Authors' conclusion
Our study suggests that arterial line complications due to thrombosis are more likely in COVID-19 patients
Study context
- Population
- Critically ill intensive care unit (ICU) patients with arterial lines, first wave of COVID-19 pandemic (March 2020)200 and 68 arterial line insertions
- Participants
- 119 vs 54
- Exposure
- COVID-19 vs non-COVID-19 sepsis/ARDS ICU patients
- COVID-19n = 119
- Sepsis/ARDSn = 54reference
- Outcome
- Arterial line removal for thrombosis (removal for any other reason as competing risk)
Methodological detailsprimary exploratory analysis, multivariable Fine-Gray subdistribution hazard model, competing risk
- Primary exploratory analysis
- Multivariable Fine-Gray subdistribution hazard model
- Competing risk
Main finding
As reported in the abstract
Adjusted subdistribution hazard ratio
2.18
95% CI 1.06–4.46
P = 0.034
COVID-19 vs Sepsis/ARDS
adjusted subdistribution HR 2.18 (95% CI 1.06–4.46); P = 0.034
Observational data: associations, not effects.
Further findings
| Outcome | COVID-19 | Sepsis/ARDS | Adjusted IRR (95% CI) | P value | |
|---|---|---|---|---|---|
| Arterial line clots per 1000 arterial line days (sensitivity analysis)Multivariable negative binomial regression | 36.3 clots per 1000 arterial line days | 19.1 clots per 1000 arterial line days | 1.78 (0.94–3.39) | P = 0.078 | |
| 0.20.5125Adjusted incidence rate ratio (log scale) |
Original publication
Thrombosis-Related Loss of Arterial Lines in the First Wave of COVID-19 and Non–COVID-19 Intensive Care Unit Patients. Anesth Analg. Published 11 October 2022. doi:10.
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