Respiratory failure & ventilation
Timing of Prone Positioning During Venovenous Extracorporeal Membrane Oxygenation for Acute Respiratory Distress Syndrome
Pooled result · Alive ICU dischargeResult — go to the resultAdjusted hazard ratio 2.52 95% CI 1.66–3.81Authors' conclusion
In a large cohort of ARDS patients on ECMO, early PP during ECMO was associated with a higher probability of being discharged alive from the ICU at 90 days and a greater improvement of Cpl,rs.
Study context
- Population
- Acute respiratory distress syndrome (ARDS) patients who underwent prone positioning during V–V extracorporeal membrane oxygenation (ECMO), European ECMO centres
- Participants
- 300 patients · 5 cohort studies
- Comparison
- Early vs late prone positioning during V-V ECMO
- Early prone positioning (PP)n = 223
- Late PPn = 77reference
- Outcome
- Probability of being discharged alive from the ICU
- Follow-up
- 90 days
Methodological detailsfive original observational cohort studies, multicentre
- Five original observational cohort studies
- Multicentre
Pooled result
Alive ICU discharge
Adjusted hazard ratio
2.52
95% CI 1.66–3.81
P < 0.001
By group
Early PP vs Late PP
aHR 2.52 (95% CI 1.66–3.81); P < 0.001
As reported in the abstract
Further pooled results
| Outcome | aHR (95% CI) | |
|---|---|---|
| Alive ICU discharge per day increase in time to PP (continuous) | 0.90 (0.87–0.93) | |
| 0.512Adjusted hazard ratio (log scale) |
Improvement of respiratory system compliance (Cpl,rs)
P = 0.038
Original publication
Timing of Prone Positioning During Venovenous Extracorporeal Membrane Oxygenation for Acute Respiratory Distress Syndrome. Crit Care Med. Published 9 November 2022. doi:10.
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