Trajectory pattern of serially measured acute kidney injury biomarkers in critically ill patients: a prospective observational study
Authors' conclusion
Trajectory pattern of serially measured urinary L-FABP was significantly associated with MAKE in ICU patients.
Study context
- Population
- Adult intensive care unit (ICU) patients with an arterial line and urethral catheter, mixed ICU, Tokyo, Japan; excluded ICU stay <48 h and known end-stage renal disease
- Participants
- 156 patients
- Exposure
- High and exponential increase vs low and constant
- Outcome
- Major adverse kidney events (MAKE): composite of death, dialysis dependency, and persistent loss of kidney function (≥ 25% decline in eGFR)
- Follow-up
- At discharge
Methodological detailssingle-centre, group-based trajectory modeling, Enrolment September 2014 to March 2015, Blood and urine samples at 0, 12, 24, and 48 h after ICU admission
- Single-centre
- Group-based trajectory modeling
- Enrolment September 2014 to March 2015
- Blood and urine samples at 0, 12, 24, and 48 h after ICU admission
Main finding
As reported in the abstract
MAKE by uL-FABP trajectory group
P < 0.001
Observational data: associations, not effects.
Further findings
| Outcome | OR (95% CI) | |
|---|---|---|
| Initial uL-FABP value and MAKE (per 1-point increase in log-transformed uL-FABP, adjusted for eGFR)Adjusted for eGFR | 1.45 (1.17–1.83) | |
| 12-h change in uL-FABP and MAKE (per 1-point increase in log-transformed uL-FABP, adjusted for eGFR)Adjusted for eGFR | 1.43 (1.12–1.88) | |
| 0.512Odds ratio (log scale) |
Estimated glomerular filtration rate (eGFR) and plasma neutrophil gelatinase-associated lipocalin (NGAL) trajectories
- Trajectory curves moved parallel to each other (low, middle, high)
Original publication
Trajectory pattern of serially measured acute kidney injury biomarkers in critically ill patients: a prospective observational study. Ann Intensive Care. Published 6 June 2024. doi:10.
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