Trajectory pattern of serum urea nitrogen to creatinine ratio in acute kidney injury requiring continuous renal replacement therapy: A post hoc analysis of a retrospective multicenter cohort study
Authors' conclusion
The groups with high UCR or high Lac levels had significantly higher mortality rates than the groups with normal UCR and Lac levels.
Study context
- Population
- Adults with acute kidney injury (AKI) treated with continuous renal replacement therapy (CRRT) at 18 university hospitals in Japan
- Participants
- 550 adults · 18 university hospitals
- Comparison
- Trajectory phenotypes: high lactate (Lac) vs high UCR vs normal UCR and Lac
- Primary endpoint
- Mortality within 7 days of CRRT termination
- Follow-up
- 7 days after CRRT termination
Methodological detailsgroup-based multitrajectory (GBMT) analysis, external validation (MIMIC-IV)
- Group-based multitrajectory (GBMT) analysis
- External validation (MIMIC-IV)
Primary result
As reported in the abstract
P < 0.01
Further findings
Serum creatinine · highest in group 3
P < 0.001
External validation (MIMIC-IV database)
- Similar results
Original publication
Trajectory pattern of serum urea nitrogen to creatinine ratio in acute kidney injury requiring continuous renal replacement therapy: A post hoc analysis of a retrospective multicenter cohort study. J Crit Care. Published 16 March 2026. doi:10.
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