Sepsis & infection

Treatment of Invasive Pulmonary Aspergillosis and Preventive and Empirical Therapy for Invasive Candidiasis in Adult Pulmonary and Critical Care Patients: An Official American Thoracic Society Clinical Practice Guideline

Am J Respir Crit Care MedPublished Clinical practice guideline

Methodological detailsGRADE approach, multidisciplinary panel
  • GRADE approach
  • Multidisciplinary panel

Recommendations

As issued by the authors

  1. Conditional recommendation; low-quality evidence

    Proven or probable invasive pulmonary aspergillosis: either initial combination therapy with a mold-active triazole plus an echinocandin or initial mold-active triazole monotherapy

  2. Conditional weak recommendation; low-quality evidence

    Against routine prophylactic or empiric antifungal agents targeting Candida species for critically ill patients without neutropenia or a history of transplant

Original publication

Treatment of Invasive Pulmonary Aspergillosis and Preventive and Empirical Therapy for Invasive Candidiasis in Adult Pulmonary and Critical Care Patients: An Official American Thoracic Society Clinical Practice Guideline. Am J Respir Crit Care Med. Published 1 January 2025. doi:10.1164/rccm.202410-2045st

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