Cardiothoracic & vascular anesthesia
Ultrafiltration During Cardiac Surgery Requiring Cardiopulmonary Bypass and Its Effect on Acute Kidney Injury
Authors' conclusion
This study suggests that conventional UF is a potential risk factor for AKI incidence following surgery with CPB. The results demonstrate an association between higher weight-adjusted ultrafiltration volume and a higher incidence of AKI.
Study context
- Population
- Adults (≥18 years) undergoing cardiac surgery with cardiopulmonary bypass (CPB) at a tertiary academic medical center, January 2018–August 2019
- Participants
- 2,369 adults
- Exposure
- Weight-adjusted conventional ultrafiltration (UF) volume: 0.1 to 17.9, 18 to 29.9 and >30 mL/kg vs 0 (no UF)
- Outcome
- Postoperative AKI (KDIGO staging criteria)
Methodological detailssingle-centre
- Single-centre
Main finding
As reported in the abstract
Postoperative AKI
Each additional 10 mL/kg UFOdds ratio (95% CI)P value
Adjusted for preoperative covariates
1.14(1.07–1.20)
P < 0.001Adjusted for preoperative and intraoperative covariates
1.07(0.99–1.16)
P = 0.076Each additional 10 mL/kg UF, as printed
- Overall postoperative acute kidney injury (AKI)
- 840 (35.4%)
Observational data: associations, not effects.
Further findings
AKI by nadir hemoglobin (Hb) (subgroup)
- Higher UF associated with increased AKI risk at nadir Hb 6 to 8 g/dL (adjusted OR, 1.24 and 1.22; p = 0.02)
- Not significantly associated with AKI at nadir Hb 10 to 12 g/dL
RBC transfusion volume
- Not related to changes in AKI incidence
Original publication
Ultrafiltration During Cardiac Surgery Requiring Cardiopulmonary Bypass and Its Effect on Acute Kidney Injury. J Cardiothorac Vasc Anesth. Published 11 October 2024. doi:10.
Composed by AI from the published abstract and checked against it. How Briefs are made →